What about prince?

Yes he was awsome!

Prince was a different level he is what I would one of the great instrumentalists of all time. Prince was definitely unique.

Jimmi Hendrix

Eddie van Halen

Ritchie Blackmore

Gilmour, reaches the parts others simply can't.

Oops, must have posted in wrong one
Anyway, is there any contest? The greatest guitarist of all time is Carlos Santana.

Nobody has mentioned Duane Allman . How about Blind Willie Johnson ?

Charles Michael «Chuck» Schuldiner&

All good indeed, but I gotta add
Gary Moore, Jeff Beck, Buddy Guy & Freddy King....these guys taught & inspired all the above.

I respect and give mad props to a lot that have been listed!

Newer guitarists....

John Petrucci - Dream Theater
John 5 - solo work, along with being Manson's and Zombie's go to touring guitarist.
Richie Kotzen - solo work, along with being C.C. Deville's replacement for Poison at one time. Better work known with The Winery Dogs.
Dimebag Darrell - Pantera
Jeff Hanneman - Slayer, R.I.P. Jeff

Damn auto correct!

Adding a few more not listed.

Yngwie Malmsteen
Micheal Schenker
Vivian Campbell
Chris Broderick
Orianthi
Phil Collen

Can't believe I forgot the man who gave Kirk Hammett from Metallica lessons.

Joe Satriani

Yeah me too. I didn't see Richie Blackmore & Mark Knopfler.

Billy Gibbons, Angus, John Mayer.

I love Gilmour but I think you are forgetting about Jeff Beck those two have an incredible talent to make strings sing.

Steve Morris

Trey Anastasio

Jimi Hendrix
Eric Clapton
Jeff Beck
Jimmy Page