My estranged wife used to do that stuff some years ago. Messed her up big time, as if she didn't already have enough mental and emotional issues.
It might just be that it affects different people in different ways, but from my experience you're better off staying away from it. Nasty stuff.
As for Mary J, I don't think there's ever been a whole lot of serious research done on it in the past? Anecdotal evidence seems to indicate that it helps some people with some medical issues. Fine. But from what I've seen over the years it makes people, well, dopey-and exacerbates some existing issues (such as alcohol dependence).
Personally, though, I think the Feds outlawing it is ridiculous. Actually I think all drugs should be legal for adults. Adults have a right to make their own decisions, even bad ones.
If drugs were legal, they would have to find another way to profile and keep the private prisons in business. Making drugs illegal has worked pretty well for them. "Legalizing" weed on the state level is just setting them up, but then again there is a lot of money in it, so they may have shot themselves in the foot on that move, like with alcohol and tobacco.
It's not about taxing the drugs either, it's about who has more money, the private prisons or the dispensaries.
I don't think the government itself is too concerned about drugs, they have other ways to fulfill their agenda.