Oh, I did find out a bit of information, but not much, so I'm slightly wiser, but not much, I'll try explain
This might explain it a bit for anti depressants, at least for Mirtazipine ( also known as remeron apparently, sounds like a villain from flash Gordon or something to me )
You know how they're forever banging on about serotonin and dopamine, and chemically imbalanced, blah blah
Well, according to t' internet , there are 15 serotonin receptor sites in your body
These are classified in 3 different groups
These 3 groups come under exciting titles as
5HT1
5HT2
And yes, if you haven't fallen asleep or slit your wrists, then you've guessed it..
5HT3
Now, it's this last 1, that I'd like to draw your attention to children,it's 1 of the 1s that our friend flash Gordon's nemesis ( in a muddle? Thank you paul weller) affects
I shall cut and paste a couple of juicy titbits from said t'interweb thingy mejig ( it's very high tech you know, no wires...look, or mirrors)
5-HT3 receptors also regulate gut motility, secretion, and peristalsis in the enteric nervous system and are involved in information transfer in the gastrointestinal tract (7). Serotonin was identified in the 1940s as a potent vasocon- strictor present in blood serum (8).Oct 4, 2012
As might be expected due to their role in emesis, 5-HT3 receptors are involved in information transfer in the gastrointestinal tract, and in the enteric nervous system they regulate gut motility and peristalsis [23].
Emesis means vomiting ( damn these Greeks and these bloody doctors obsession with them, why couldn't they just say spewing up like everybody else, it's a form of legalese you know, don't get me started) sounds like nemesis don't it?
The enteric nervous system or intrinsic nervous system is one of the main divisions of the autonomic nervous system and consists of a mesh-like system of neurons that governs the function of the gastrointestinal
Peristalsis, involuntary movements of the longitudinal and circular muscles, primarily in the digestive tract but occasionally in other hollow tubes of the body, that occur in progressive wavelike contractions. Peristaltic waves occur in the esophagus, stomach, and intestines.( somebody is full of $hit huh, feeling better sir? Fuc$ off)
Motility is the ability of an organism to move independently, using metabolic energy.
Now I had to look those 4 things up
, perhaps you didn't have to. Now please, correct me if I'm wrong. I ain't no rocket scientist but I like to think that I'm reasonably smart, and as a Yorkshire man I'm pithy ( hear that bastardo doctors, pithy) , so I'd say, that in my most humble, scientific and expert opinion, and all that jazz..
That it....
Wait ( no pun intended) for it...
Drum roll please....
Affects your bleeding stomach, guts, metabolism call it what you will
And if it does that...
Then...
That might explain...
Zzzzz, I fell asleep...sorry
well done for doing your own research .
What you describe represents only part of the equation . The most important being the effect blocking the receptors has on the hypothalamus in the brain . The hypothalamus produces and secretes neurotransmitters (such as serotonin and dopamine ) . It also controls the endocrine system and release of important horomones that regulate homeostatic functions .....including temperature control , eating , metabolism , energy maintenance , and stress control. Both hormones and neurotransmitters are involved in the day to day functions of the body ...
Medications which block receptor cells involved in these processes alter the signals to the hypothalamus , which affects the amount of hormones released , and changes the action response of the hormone . If those receptors are linked to energy ., then a disruption would produce fatigue ... if metabolic then blood sugar., fat metabolism and appetite would be affected . Similarly if receptor cells are blocked by the action of a medication then neurotransmitters cannot bind to the receptor site and the chemical message they send is altered . The feedback loop to the brain is disrupted and the hypothalamus responds accordingly by either increasing or decreasing hormones and neurotransmitter release . It is a very complex system that endeavours to maintain equilibrium .
The other important factor is genetics . The number and type of regulator cells a person has is controlled by genetics . Some people will be affected more than others simply because of their genetic makeup .. in this scenario .. the H2TCR gene which regulates serotonin receptors is an important determinant in individual response to antipsychotic medication uptake .
Lifestyle choices around diet and exercise , stress , sleep etc are likely contributors to weight gain /fatigue ..the influence Lifestyle has should not be discounted .
Edited by
Blondey111
on Thu 12/17/20 11:41 PM